Mechanisms of Osteoarthritis (OA) Pain

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Pain and OA.

Osteoarthritis (OA), in which joint degeneration leads to a loss of mobility and function, is one of the most common causes of disability. The most prominent feature but least studied aspect of OA is joint pain. The World Health Organisation recently estimated that about 10% of the world’s population over the age of 60 years suffers from OA pain which equates to an enormous socioeconomic concer...

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Osteoarthritis (OA) is the most common form of arthritis, affecting about 15% of persons over 60 years of age. Osteoarthritis is the most common cause of disability and a major source of pain and functional limitations. Up to one-half of people aged 50 and over report knee pain during the course of the year, and a quarter have severe and disabling pain. With the aging population and increasing ...

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Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA)

OBJECTIVES To address the hypothesis that different types of established osteoarthritis (OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate (MIA) in the rat. METHODS Rats received a single intra-arti...

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A current review of molecular mechanisms regarding osteoarthritis and pain.

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of life and increased health costs. To understand this disease, physicians have been studying risk factors, such as genetic predisposition, aging, obesity, and joint malalignment; however have been unable to conclusively determine the direct etiology. Current treatment options are short-term or ineffe...

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INTRODUCTION Pain is the primary outcome measurement in osteoarthritis, and its assessment is mostly based on its intensity. The management of this difficult chronic condition could be improved by using pain descriptors to improve analyses of painful sensations. This should help to define subgroups of patients based on pain phenotype, for more adapted treatment. This study draws upon patients' ...

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ژورنال

عنوان ژورنال: Current Osteoporosis Reports

سال: 2018

ISSN: 1544-1873,1544-2241

DOI: 10.1007/s11914-018-0477-1